This website uses cookies to keep you logged in between sessions and to collect anonymized traffic statistics.
Learn more
Available data Protein details
TOP1
7164aaf3-4427-4253-8f95-e93f801d3046
Targeting drugs
The protein is currently assigned to 12 targeting drug values.
# Data Value Internal External
DrugBank Drug ID DB00762 Details Details
DrugBank Drug ID DB01030 Details Details
DrugBank Drug ID DB04967 Details Details
DrugBank Drug ID DB05630 Details Details
DrugBank Drug ID DB12893 Details Details
DrugBank Drug ID DB14962 Details Details
DrugBank Drug Name Irinotecan Details -
DrugBank Drug Name Lucanthone Details -
DrugBank Drug Name Sacituzumab govitecan Details -
DrugBank Drug Name Sodium stibogluconate Details -
DrugBank Drug Name Topotecan Details -
DrugBank Drug Name Trastuzumab deruxtecan Details -
Databases
The protein is currently assigned to 6 databases.
# Database Links
HGNC Details
Ensembl Details
UniProt Details
NCBI Details
InnateDB Details
DrugBank Details
Values
The protein is currently assigned to 20 values.
# Data Value Internal External
HGNC ID 11986 Details Details
HGNC Symbol TOP1 Details -
HGNC Name DNA topoisomerase I Details -
Ensembl ID ENSG00000198900 Details Details
UniProt ID P11387 Details Details
UniProt Title TOP1_HUMAN Details -
NCBI ID 7150 Details Details
InnateDB ID 75139 Details Details
DrugBank Drug ID DB00762 Details Details
DrugBank Drug ID DB01030 Details Details
DrugBank Drug ID DB04967 Details Details
DrugBank Drug ID DB05630 Details Details
DrugBank Drug ID DB12893 Details Details
DrugBank Drug ID DB14962 Details Details
DrugBank Drug Name Irinotecan Details -
DrugBank Drug Name Lucanthone Details -
DrugBank Drug Name Sacituzumab govitecan Details -
DrugBank Drug Name Sodium stibogluconate Details -
DrugBank Drug Name Topotecan Details -
DrugBank Drug Name Trastuzumab deruxtecan Details -
Interactions
The protein is currently assigned to 100 interactions.
# Interaction Type Links
TOP1 - LIG1 Source Details
HNRNPM - TOP1 Target Details
TOP1 - TRIM26 Source Details
TOP1 - H3C7 Source Details
S100A9 - TOP1 Target Details
COX15 - TOP1 Target Details
NCL - TOP1 Target Details
TOP1 - TPR Source Details
PARP1 - TOP1 Target Details
TOP1 - VCAM1 Source Details
TOP1 - APLF Source Details
CDKN2A - TOP1 Target Details
CSNK2A1 - TOP1 Target Details
TOP1 - DUS4L Source Details
TOP1 - LIG3 Source Details
NKX3-1 - TOP1 Target Details
TOP1 - SF3B1 Source Details
EIF2AK2 - TOP1 Target Details
TOP1 - H3C12 Source Details
IK - TOP1 Target Details
LAMB3 - TOP1 Target Details
NRF1 - TOP1 Target Details
ELAVL1 - TOP1 Target Details
TOP1 - H3C11 Source Details
ALDH1B1 - TOP1 Target Details
RPS14 - TOP1 Target Details
STAT1 - TOP1 Target Details
TOP1 - BTBD1 Source Details
TOP1 - H2BC21 Source Details
TOP1 - XRCC5 Source Details
RBL2 - TOP1 Target Details
TOP1 - EFTUD2 Source Details
TOP1 - VDAC1 Source Details
PRKDC - TOP1 Target Details
DLST - TOP1 Target Details
TOP1 - ASXL3 Source Details
TOP1 - H3C10 Source Details
NONO - TOP1 Target Details
TOP1 - TOPORS Source Details
TOP1 - H3C3 Source Details
JUN - TOP1 Target Details
PDHA1 - TOP1 Target Details
CDK1 - TOP1 Target Details
TOP1 - SRSF11 Source Details
TOP1 - ZRANB2 Source Details
TOP1 - H3C2 Source Details
PCNA - TOP1 Target Details
TOP1 - SUPT16H Source Details
TOP1 - EAF1 Source Details
TOP1 - NLRP3 Source Details
HNRNPC - TOP1 Target Details
SMAD2 - TOP1 Target Details
TOP1 - RBM14 Source Details
TOP1 - ADAMTS16 Source Details
TOP1 - ESAM Source Details
PRKCA - TOP1 Target Details
TOP1 - CDT1 Source Details
SNRPD1 - TOP1 Target Details
CSNK2A2 - TOP1 Target Details
TOP1 - EED Source Details
TOP1 - BTBD2 Source Details
TOP1 - DDX17 Source Details
SUMO2 - TOP1 Target Details
PRICKLE3 - TOP1 Target Details
TOP1 - UBC Source Details
EED - TOP1 Target Details
SLC25A3 - TOP1 Target Details
SFPQ - TOP1 Target Details
TOP1 - CIDEC Source Details
CEBPB - TOP1 Target Details
MYC - TOP1 Target Details
TOP1 - H3C1 Source Details
TOP1 - RBM39 Source Details
SRSF1 - TOP1 Target Details
GTF2E2 - TOP1 Target Details
EGFR - TOP1 Target Details
TOP1 - SUMO1 Source Details
TOP1 - H3C8 Source Details
OAS3 - TOP1 Target Details
TOP1 - UTP20 Source Details
MDM2 - TOP1 Target Details
RNF2 - TOP1 Target Details
TOP1 - TOP2A Source Details
CDK2 - TOP1 Target Details
FSHR - TOP1 Target Details
ABL1 - TOP1 Target Details
TOP1 - TP53 Source Details
SNRPG - TOP1 Target Details
TOP1 - H3C4 Source Details
TOP1 - NCSTN Source Details
TOP1 - H3C6 Source Details
TOP1 - MACROH2A1 Source Details
NOP2 - TOP1 Target Details
SUMO3 - TOP1 Target Details
HNRNPA1 - TOP1 Target Details
ALDH2 - TOP1 Target Details
TOP1 - UBE2I Source Details
H3-3B - TOP1 Target Details
TOP1 - SF3B6 Source Details
GTF3C1 - TOP1 Target Details
Collections
The protein is currently assigned to 64 collections.
# Collection Links
Essential genes for cell-line MDA-MB-436 Details
Mutated genes for cell-line HT55 Details
Mutated genes for cell-line SW48 Details
Mutated genes for cell-line KMCH1 Details
Mutated genes for cell-line OCUM1 Details
Essential genes for cell-line MDA-MB-361 Details
Mutated genes for cell-line 639V Details
Essential genes for cell-line PaTu_8988S Details
Essential genes for cell-line HPAF-II Details
Mutated genes for cell-line NCIH650 Details
Mutated genes for cell-line SNU308 Details
Mutated genes for cell-line CAL851 Details
Essential genes for cell-line KP-3 Details
Mutated genes for cell-line MERO41 Details
Essential genes for cell-line Capan-2 Details
Mutated genes for cell-line SUDHL6 Details
Essential genes for cell-line SK-BR-3 Details
Essential genes for cell-line HCC1954 Details
Mutated genes for cell-line NP8 Details
Mutated genes for cell-line NCIH1155 Details
DrugBank drug-targets for biotech drugs Details
Mutated genes for cell-line ES6 Details
Mutated genes for cell-line GSS Details
DrugBank drug-targets for investigational drugs Details
Essential genes for cell-line PL45 Details
Mutated genes for cell-line NCIH596 Details
Mutated genes for cell-line UMUC11 Details
Mutated genes for cell-line MON Details
Essential genes for cell-line OV-90 Details
Mutated genes for cell-line NCIH526 Details
Mutated genes for cell-line COLO824 Details
Mutated genes for cell-line HCC38 Details
Mutated genes for cell-line SNU638 Details
Essential genes for cell-line MIA_PaCa-2 Details
Mutated genes for cell-line SNUC2A Details
Mutated genes for cell-line HRT18 Details
Essential genes for cell-line HPDE Details
Mutated genes for cell-line UMUC4 Details
Mutated genes for cell-line TEN Details
DrugBank drug-targets for small molecule drugs Details
Essential genes for cell-line MDA-MB-157 Details
Mutated genes for cell-line JHUEM1 Details
Essential genes for cell-line HCC1187 Details
DrugBank drug-targets for all drugs Details
Mutated genes for cell-line KARPAS299 Details
Essential genes for cell-line 609050M Details
Essential genes for cell-line HCC1143 Details
Mutated genes for cell-line NCIH1618 Details
Essential genes for cell-line OVCA8 Details
Mutated genes for cell-line HSC2 Details
Mutated genes for cell-line H4 Details
Mutated genes for cell-line UMUC1 Details
Mutated genes for cell-line BCP1 Details
Mutated genes for cell-line SW1710 Details
Essential genes for cell-line HCC1395 Details
Mutated genes for cell-line OCIC4P Details
Essential genes for cell-line KPL-1 Details
DrugBank drug-targets for approved drugs Details
Mutated genes for cell-line NCIH838 Details
Mutated genes for cell-line HCC1359 Details
Mutated genes for cell-line DND41 Details
Mutated genes for cell-line SNUC2B Details
Mutated genes for cell-line ICC137 Details
Essential genes for cell-line Panc_02 Details