Available data Protein details
IRS1
eb34004c-9080-4d2f-8229-ca7da57bf5bf
Targeting drugs
There are no targeting drug values currently assigned.
Databases
The protein is currently assigned to 5 databases.
# Database Links
HGNC Details
Ensembl Details
UniProt Details
NCBI Details
InnateDB Details
Values
The protein is currently assigned to 9 values.
# Data Value Internal External
HGNC ID 6125 Details Details
HGNC Symbol IRS1 Details -
HGNC Name insulin receptor substrate 1 Details -
HGNC Alias HIRS-1 Details -
Ensembl ID ENSG00000169047 Details Details
UniProt ID P35568 Details Details
UniProt Title IRS1_HUMAN Details -
NCBI ID 3667 Details Details
InnateDB ID 82407 Details Details
Interactions
The protein is currently assigned to 221 interactions.
# Interaction Type Links
IRS1 - PRDM14 Source Details
IRS1 - PIK3R1 Source Details
IRS1 - LTK Source Details
CHUK - IRS1 Target Details
RPS6KB1 - IRS1 Target Details
IRS1 - YWHAB Source Details
LYN - IRS1 Target Details
AR - IRS1 Target Details
SOCS7 - IRS1 Target Details
IRS1 - PTPRU Source Details
IRS1 - ARMC1 Source Details
IRS1 - KHDRBS1 Source Details
PRKCD - IRS1 Target Details
TNF - IRS1 Target Details
LEP - IRS1 Target Details
MAPK9 - IRS1 Target Details
IRS1 - IRS4 Source Details
AGT - IRS1 Target Details
MIR145 - IRS1 Target Details
BCL2 - IRS1 Target Details
IRS1 - IRS1 Source Details
IRS1 - IRS1 Target Details
IRS1 - RPTOR Source Details
IRS1 - CDK1 Source Details
EIF2S1 - IRS1 Target Details
NTRK3 - IRS1 Target Details
GSK3B - IRS1 Target Details
IRS1 - PABPC1 Source Details
PTK2 - IRS1 Target Details
GKN2 - IRS1 Target Details
SLC2A4 - IRS1 Target Details
IRS1 - INSR Source Details
IRS1 - RAP1GDS1 Source Details
PRKCB - IRS1 Target Details
IRS1 - YWHAH Source Details
IRS1 - CRK Source Details
ESR1 - IRS1 Target Details
PRKCG - IRS1 Target Details
MCF2L2 - IRS1 Target Details
IL4R - IRS1 Target Details
CSNK2A2 - IRS1 Target Details
PDPK1 - IRS1 Target Details
RPS6KA2 - IRS1 Target Details
SMAD3 - IRS1 Target Details
CSNK2A1 - IRS1 Target Details
AKT1 - IRS1 Target Details
GRB10 - IRS1 Target Details
IRS1 - GRB2 Source Details
IRS1 - AKT2 Source Details
ROCK2 - IRS1 Target Details
IRS1 - ARMC7 Source Details
IL6 - IRS1 Target Details
IRS1 - UBC Source Details
INSR - IRS1 Target Details
IRS1 - PKP3 Source Details
CBLB - IRS1 Target Details
APP - IRS1 Target Details
IRS1 - CBL Source Details
IRS1 - PTPRD Source Details
IRS1 - RPS6KB1 Source Details
PIK3R1 - IRS1 Target Details
GHR - IRS1 Target Details
IRS1 - REST Source Details
IRS1 - PIM2 Source Details
CTNNB1 - IRS1 Target Details
IRS1 - GRAP Source Details
GRK2 - IRS1 Target Details
IRS1 - PLK1 Source Details
PRKCA - IRS1 Target Details
IRS1 - ARMC3 Source Details
PRKCQ - IRS1 Target Details
YWHAH - IRS1 Target Details
RPS6KB2 - IRS1 Target Details
IRS1 - MAPK1 Source Details
IRS1 - PRKCQ Source Details
IRS1 - SOCS7 Source Details
IRS1 - KRT17 Source Details
IRS1 - MAPK3 Source Details
IRS1 - SOCS1 Source Details
IRS1 - KPNA5 Source Details
IRS1 - MTOR Source Details
LTK - IRS1 Target Details
BCL2L1 - IRS1 Target Details
IRS1 - NCK2 Source Details
PIM3 - IRS1 Target Details
RPS6KA1 - IRS1 Target Details
MAPK14 - IRS1 Target Details
IKBKB - IRS1 Target Details
MTOR - IRS1 Target Details
IRS1 - KPNA1 Source Details
EP300 - IRS1 Target Details
IRS1 - PIK3R2 Source Details
IRS1 - LRRK2 Source Details
FOXA1 - IRS1 Target Details
PRKCZ - IRS1 Target Details
IRS1 - BCAR3 Source Details
IGF1 - IRS1 Target Details
IRS1 - PRKCB Source Details
PRKAA2 - IRS1 Target Details
IRS1 - MAPK8 Source Details
JUN - IRS1 Target Details
IRS1 - CSK Source Details
IRS1 - SHC1 Source Details
IRS1 - NCK1 Source Details
IRS1 - ARMC8 Source Details
CSK - IRS1 Target Details
IRS1 - AKT1 Source Details
NTRK1 - IRS1 Target Details
IGF1R - IRS1 Target Details
JAK2 - IRS1 Target Details
IRS1 - IRS2 Source Details
MAPK3 - IRS1 Target Details
APLN - IRS1 Target Details
PIM1 - IRS1 Target Details
JAK1 - IRS1 Target Details
GAB1 - IRS1 Target Details
RPS6KA5 - IRS1 Target Details
AP3S1 - IRS1 Target Details
CTNND2 - IRS1 Target Details
IRS1 - SPAG6 Source Details
IRS1 - PELI1 Source Details
IRS1 - PTK2 Source Details
IRS1 - NISCH Source Details
IGF2 - IRS1 Target Details
RPS6KA3 - IRS1 Target Details
GATA2 - IRS1 Target Details
CTNND1 - IRS1 Target Details
PMAIP1 - IRS1 Target Details
PRKAB1 - IRS1 Target Details
ATR - IRS1 Target Details
CNR1 - IRS1 Target Details
OGT - IRS1 Target Details
IRS1 - SIRT1 Source Details
IRS1 - PIK3CG Source Details
CSNK1A1 - IRS1 Target Details
GRB2 - IRS1 Target Details
IRS1 - JAK2 Source Details
CDK2 - IRS1 Target Details
IRS1 - UBTF Source Details
IRS1 - ARMC6 Source Details
CDK1 - IRS1 Target Details
TBC1D4 - IRS1 Target Details
DVL2 - IRS1 Target Details
IRS1 - CAV1 Source Details
IRS1 - FOXP3 Source Details
IRS1 - FBXW8 Source Details
MAP2K2 - IRS1 Target Details
ROCK1 - IRS1 Target Details
PRKACA - IRS1 Target Details
IRS1 - PRKCA Source Details
ALK - IRS1 Target Details
MAPK1 - IRS1 Target Details
IRS1 - PIM3 Source Details
RPS6KA4 - IRS1 Target Details
IRS1 - PIK3R3 Source Details
IRS1 - PIK3CA Source Details
CSNK2B - IRS1 Target Details
DDR1 - IRS1 Target Details
IRS1 - YWHAZ Source Details
IRS1 - JAK1 Source Details
IRS1 - YWHAE Source Details
PTH - IRS1 Target Details
CRP - IRS1 Target Details
NTRK2 - IRS1 Target Details
IRS1 - PRKCD Source Details
PTPN1 - IRS1 Target Details
SIK2 - IRS1 Target Details
MAPK8 - IRS1 Target Details
IRS1 - ANKAR Source Details
CBL - IRS1 Target Details
IRS1 - CUL7 Source Details
EIF4E - IRS1 Target Details
PIM2 - IRS1 Target Details
CSF1R - IRS1 Target Details
IRS1 - PKP4 Source Details
PTPN13 - IRS1 Target Details
IRS1 - SMAD3 Source Details
ERBB2 - IRS1 Target Details
RPS6 - IRS1 Target Details
FOXA2 - IRS1 Target Details
ARVCF - IRS1 Target Details
GRB14 - IRS1 Target Details
IRS1 - PIM1 Source Details
IRS1 - KPNA6 Source Details
IRS1 - CHUK Source Details
PTPRF - IRS1 Target Details
EIF2AK2 - IRS1 Target Details
ETS1 - IRS1 Target Details
JAK3 - IRS1 Target Details
PTPN11 - IRS1 Target Details
MAP2K1 - IRS1 Target Details
IRS1 - PRKCZ Source Details
PRKDC - IRS1 Target Details
PLK1 - IRS1 Target Details
TG - IRS1 Target Details
IRS1 - PTPRF Source Details
SIK1 - IRS1 Target Details
IRS1 - PTPN1 Source Details
IRS1 - PTK6 Source Details
SOCS3 - IRS1 Target Details
AP2M1 - IRS1 Target Details
IRS1 - NUMB Source Details
FYN - IRS1 Target Details
IRS1 - JAK3 Source Details
HDAC2 - IRS1 Target Details
INS - IRS1 Target Details
IRS1 - PKP2 Source Details
PIK3CA - IRS1 Target Details
GNB2 - IRS1 Target Details
MAP2K7 - IRS1 Target Details
IRS1 - NEDD4 Source Details
ST3GAL4 - IRS1 Target Details
IRS1 - NTRK1 Source Details
IRS1 - PIK3CB Source Details
IRS1 - PTPN11 Source Details
IRS1 - TRIM72 Source Details
IRS1 - SOCS3 Source Details
IL1B - IRS1 Target Details
EGF - IRS1 Target Details
EGFR - IRS1 Target Details
IRS1 - IKBKB Source Details
Collections
The protein is currently assigned to 136 collections.
# Collection Links
Mutated genes for cell-line KMS11 Details
Mutated genes for cell-line CI Details
Mutated genes for cell-line HT55 Details
Mutated genes for cell-line SLVL Details
Mutated genes for cell-line SW48 Details
Mutated genes for cell-line NCIH64 Details
Mutated genes for cell-line NCIH1694 Details
Mutated genes for cell-line WSUNHL Details
Mutated genes for cell-line SNU478 Details
Mutated genes for cell-line SW954 Details
Mutated genes for cell-line HTCC3 Details
Mutated genes for cell-line MUTZ8 Details
Mutated genes for cell-line COV318 Details
Mutated genes for cell-line S117 Details
Mutated genes for cell-line GRST Details
Mutated genes for cell-line HSC1 Details
Mutated genes for cell-line SBC3 Details
Mutated genes for cell-line F5 Details
Mutated genes for cell-line CCK81 Details
Mutated genes for cell-line JMSU1 Details
Mutated genes for cell-line HT1376 Details
Mutated genes for cell-line LCLC103H Details
Essential genes for cell-line IMIM-PC-2 Details
Mutated genes for cell-line NCIH650 Details
Mutated genes for cell-line SNUC5 Details
Mutated genes for cell-line SW684 Details
Mutated genes for cell-line KMS26 Details
Mutated genes for cell-line NALM6 Details
Mutated genes for cell-line HMCB Details
Mutated genes for cell-line OCIAML5 Details
Mutated genes for cell-line A498 Details
Mutated genes for cell-line CTV1 Details
Mutated genes for cell-line GB1 Details
Mutated genes for cell-line NCIH1339 Details
Essential genes for cell-line IMIM-PC-1 Details
Mutated genes for cell-line VMRCLCD Details
Mutated genes for cell-line ICC5 Details
Mutated genes for cell-line HEC6 Details
Mutated genes for cell-line MKN45 Details
Mutated genes for cell-line GAK Details
Mutated genes for cell-line CHL1 Details
Mutated genes for cell-line IGROV1 Details
Essential genes for cell-line HCC1954 Details
Mutated genes for cell-line ACN Details
Mutated genes for cell-line HS840T Details
Mutated genes for cell-line FARAGE Details
Mutated genes for cell-line PMFKO14 Details
Mutated genes for cell-line LC41 Details
Mutated genes for cell-line A431 Details
Mutated genes for cell-line CHLA10 Details
Mutated genes for cell-line DU145 Details
Mutated genes for cell-line HCE4 Details
Mutated genes for cell-line NCIH23 Details
Mutated genes for cell-line PC3JPC3 Details
Mutated genes for cell-line HCC515 Details
Mutated genes for cell-line NCIH2196 Details
Essential genes for cell-line PANC-1 Details
Mutated genes for cell-line NCIH187 Details
Mutated genes for cell-line WM88 Details
Mutated genes for cell-line ICC9 Details
Mutated genes for cell-line OVISE Details
Essential genes for cell-line HCC1937 Details
Mutated genes for cell-line NCIH526 Details
Mutated genes for cell-line TDOTT Details
Mutated genes for cell-line MOLM16 Details
Mutated genes for cell-line LS180 Details
Mutated genes for cell-line HRT18 Details
Mutated genes for cell-line PACADD137 Details
Mutated genes for cell-line TE10 Details
Mutated genes for cell-line 95T1000 Details
Mutated genes for cell-line HEC265 Details
Mutated genes for cell-line MCF7 Details
Mutated genes for cell-line MOLT4 Details
Mutated genes for cell-line CII Details
Mutated genes for cell-line PC3 Details
Mutated genes for cell-line SNUC1 Details
Mutated genes for cell-line MZ7MEL Details
Mutated genes for cell-line SISO Details
Mutated genes for cell-line LOVO Details
Mutated genes for cell-line KM12 Details
Mutated genes for cell-line NCIH929 Details
Mutated genes for cell-line YD15 Details
Mutated genes for cell-line OC316 Details
Mutated genes for cell-line SNU1544 Details
Mutated genes for cell-line OE19 Details
Mutated genes for cell-line ANGMCSS Details
Mutated genes for cell-line MDAMB361 Details
Mutated genes for cell-line RKO Details
Mutated genes for cell-line TE5 Details
Mutated genes for cell-line SUPHD1 Details
Mutated genes for cell-line MOLP2 Details
Mutated genes for cell-line NCIH1651 Details
Mutated genes for cell-line HHUA Details
Mutated genes for cell-line DV90 Details
Mutated genes for cell-line NZOV9 Details
Mutated genes for cell-line CHLA9 Details
Mutated genes for cell-line OVMIU Details
Mutated genes for cell-line KNS60 Details
Mutated genes for cell-line MZ7B Details
Mutated genes for cell-line BT474 Details
Mutated genes for cell-line SQ1 Details
Mutated genes for cell-line SARC9371 Details
Mutated genes for cell-line HEC151 Details
Mutated genes for cell-line PACADD165 Details
Mutated genes for cell-line SNGM Details
Mutated genes for cell-line 2313287 Details
Mutated genes for cell-line NCIH520 Details
Mutated genes for cell-line KARPAS620 Details
Mutated genes for cell-line H2803 Details
Mutated genes for cell-line MHHPREB1 Details
Mutated genes for cell-line MOLT16 Details
Mutated genes for cell-line OVCA433 Details
Mutated genes for cell-line LS1034 Details
Mutated genes for cell-line CAL120 Details
Mutated genes for cell-line OC314 Details
Mutated genes for cell-line PK45H Details
Mutated genes for cell-line LN464 Details
Mutated genes for cell-line NCIH2110 Details
Mutated genes for cell-line DND41 Details
Mutated genes for cell-line HS737T Details
Mutated genes for cell-line NCIH322 Details
Mutated genes for cell-line SNU407 Details
Mutated genes for cell-line SNU685 Details
Mutated genes for cell-line KPNRTBM1 Details
Mutated genes for cell-line HSB2 Details
Mutated genes for cell-line NCIH841 Details
Mutated genes for cell-line PANC0213 Details
Mutated genes for cell-line UMUC14 Details
Mutated genes for cell-line SNU324 Details
Mutated genes for cell-line NCIH2172 Details
Mutated genes for cell-line KPL1 Details
Mutated genes for cell-line NCIH1105 Details
Mutated genes for cell-line HEC1 Details
Essential genes for cell-line KP-4 Details
Mutated genes for cell-line ISHIKAWAHERAKLIO02ER Details
Mutated genes for cell-line HCT116 Details